Among postmenopausal women, lifestyle change involving diet, exercise, or both combined over 1 year improves body weight and adiposity, with the greatest change arising from the combined intervention. BMI, waist circumference, and % body fat were also similarly reduced. C), while the C group experienced a non-significant −0.8% decrease. Using an intention-to-treat analysis, average weight loss at 12 months was −8.5% for the D group (P<0.0001 vs.
399 women completed the trial (91% retention). Baseline and 12-month weight and adiposity measures were obtained by staff blinded to participants’ intervention assignment. Participants were predominantly non-Hispanic Whites (85%) with a mean age of 58.0±5.0 years, a mean BMI of 30.9±4.0 kg/m 2 and an average of 47.8±4.4% body fat. The group-based dietary intervention had a weight-reduction goal of ≥10%, and the exercise intervention consisted of a gradual escalation to 45 min aerobic exercise 5 d/wk. a no-lifestyle-change control (C) on change in body weight and composition. We conducted a year-long, 4-arm randomized trial among 439 overweight-to-obese postmenopausal sedentary women to determine the effects of a calorie-reduced, low-fat diet (D), a moderate-intensity, facility-based aerobic exercise program (E), or the combination of both interventions (D+E), vs. This is particularly true for postmenopausal women a population with a high prevalence of obesity yet towards whom fewer studies are targeted. Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated.